@article{bastard:hal-03358792,
TITLE = {Autoantibodies neutralizing type I IFNs are present in ~4\% of uninfected individuals over 70 years old and account for ~20\% of COVID-19 deaths},
AUTHOR = {Bastard, Paul and Gervais, Adrian and Le Voyer, Tom and Rosain, Jeremie and Philippot, Quentin and Manry, J{\'e}r{\'e}my and Michailidis, Eleftherios and Hoffmann, Hans-Heinrich and Eto, Shohei and Garcia-Prat, Marina and Bizien, Lucy and Parra-Martinez, Alba and Yang, Rui and Haljasmagi, Liis and Migaud, Melanie and Sarekannu, Karita and Maslovskaja, Julia and de Prost, Nicolas and Tandjaoui-Lambiotte, Yacine and Luyt, Charles-Edouard and Amador-Borrero, Blanca and Gaudet, Alexandre and Poissy, Julien and Morel, Pascal and Richard, Pascale and Cognasse, Fabrice and Troya, Jesus and Trouillet-Assant, Sophie and Belot, Alexandre and Saker, Kahina and Garcon, Pierre and Riviere, Jacques G. and Lagier, Jean-Christophe and Gentile, Stephanie and Rosen, Lindsey B. and Shaw, Elana and Morio, Tomohiro and Tanaka, Junko and Dalmau, David and Tharaux, Pierre-Louis and Sene, Damien and Stepanian, Alain and Megarbane, Bruno and Triantafyllia, Vasiliki and Fekkar, Arnaud and Heath, James R. and Franco, Jose Luis and Anaya, Juan-Manuel and Sole-Violan, Jordi and Imberti, Luisa and Biondi, Andrea and Bonfanti, Paolo and Castagnoli, Riccardo and Delmonte, Ottavia M. and Zhang, Yu and Snow, Andrew L. and Holland, Steven M. and Biggs, Catherine and Moncada-Velez, Marcela and Arias, Andres Augusto and Lorenzo, Lazaro and Boucherit, Soraya and Coulibaly, Boubacar and Anglicheau, Dany and Planas, Anna M. and Haerynck, Filomeen and Duvlis, Sotirija and Nussbaum, Robert L. and Ozcelik, Tayfun and Keles, Seygi and Bousfiha, Ahmed A. and El Bakkouri, Jalila and Ramirez-Santana, Carolina and Paul, St{\'e}phane and Pan-Hammarstrom, Qiang and Hammarstrom, Lennart and Dupont, Annabelle and Kurolap, Alina and Metz, Christine N. and Aiuti, Alessandro and Casari, Giorgio and Lampasona, Vito and Ciceri, Fabio and Barreiros, Lucile A. and Dominguez-Garrido, Elena and Vidigal, Mateus and Zatz, Mayana and van de Beek, Diederik and Sahanic, Sabina and Tancevski, Ivan and Stepanovskyy, Yurii and Boyarchuk, Oksana and Nukui, Yoko and Tsumura, Miyuki and Vidaur, Loreto and Tangye, Stuart G. and Burrel, Sonia and Duffy, Darragh and Quintana-Murci, Lluis and Klocperk, Adam and Kann, Nelli Y. and Shcherbina, Anna and Lau, Yu-Lung and Leung, Daniel and Coulongeat, Matthieu and Marlet, Julien and Koning, Rutger and Reyes, Luis Felipe and Chauvineau-Grenier, Angelique and Venet, Fabienne and Monneret, Guillaume and Nussenzweig, Michel C. and Arrestier, Romain and Boudhabhay, Idris and Baris-Feldman, Hagit and Hagin, David and Wauters, Joost and Meyts, Isabelle and Dyer, Adam H. and Kennelly, Sean P. and Bourke, Nollaig M. and Halwani, Rabih and Sharif-Askari, Narjes Saheb and Dorgham, Karim and Sallette, Jerome and Sedkaoui, Souad Mehlal and Alkhater, Suzan and Rigo-Bonnin, Raul and Morandeira, Francisco and Roussel, Lucie and Vinh, Donald C. and Ostrowski, Sisse Rye and Condino-Neto, Antonio and Prando, Carolina and Bonradenko, Anastasiia and Spaan, Andras N. and Gilardin, Laurent and Fellay, Jacques and Lyonnet, Stanislas and Bilguvar, Kaya and Lifton, Richard P. and Mane, Shrikant and Lab, Hgid and Clinicians, Covid and Clinicians, Covid-Storm and Group, Niaid Immune Response To Covid and Group, Nh-Covair Study and Danish, Chge and Danish Blood Donor, Study and St. James'S, Hospital and Group, Sars Cov2 Interest and French, Covid Cohort Study Group and Imagine, Covid-Group and Milieu Interieur, Consortium and Co, V. Contact Cohort and Amsterdam, U. M. C. Covid and Biobank, Investigators and Effort, Covid Human Genetic and Cohort, Constances and Study, C. Dijon and Cerba, Health-Care and Etablissement Du Sang Study, Group and Anderson, Mark S. and Boisson, Bertrand and Beziat, Vivien and Zhang, Shen-Ying and Vandreakos, Evangelos and Hermine, Olivier and Pujol, Aurora and Peterson, Part and Mogensen, Trine H. and Rowen, Lee and Mond, James and Debette, Stephanie and de Lamballerie, Xavier and Duval, Xavier and Mentr{\'e},
France and Zins, Marie and Soler-Palacin, Pere and Colobran, Roger and Gorochov, Guy and Solanich, Xavier and Susen, Sophie and Martinez-Picado, Javier and Raoult, Didier and Vasse, Marc and Gregersen, Peter K. and Piemonti, Lorenzo and Rodriguez-Gallego, Carlos and Notarangelo, Luigi D. and Su, Helen C. and Kisand, Kai and Okada, Satoshi and Puel, Anne and Jouanguy, Emmanuelle and Rice, Charles M. and Tiberghien, Pierre and Zhang, Qian and Cobat, Aurelie and Abel, Laurent and Casanova, Jean-Laurent and Richard, Jean-Christophe and Rodero, Mathieu P and van Der Werf, Sylvie and Andr{\'e}jak, Claire},
URL = {https://hal.science/hal-03358792},
JOURNAL = {Science Immunology},
PUBLISHER = {American Association for the Advancement of Science (AAAS)},
VOLUME = {6},
NUMBER = {62},
PAGES = {eabl4340},
YEAR = {2021},
MONTH = Aug, DOI = {10.1126/sciimmunol.abl4340},
PDF = {https://hal.science/hal-03358792/file/BPH_SI_2021_Bastard.pdf},
HAL_ID = {hal-03358792},
HAL_VERSION = {v1},
}